Hafizur, R.M. Boath, A.S.; Stewart, D.; McDougall, G.J. (super-)engineered plastics) to biomedical domains (e.g. Cinnamic acid derivatives that have been reported by researchers include ferulic acid, curcumin [ 11 ], caffeic acid, p-hydroxycinnamic acid [ 14] coumaric and chlorogenic acids [ 15 ], etc. ; Cheng, J.T. Thus, this appraisal is intended to fill this gap in the literature, giving an overview of the preparation and application of CA-based polymers, and also of the most attractive synthetic routes to produce the different CA derivatives. Needless to say, it is possible according to the invention to use cinnamic acid or its derivatives alone or as a mixture. Cinnamaldehyde derivatives possess various alkyl, alkoxy or bromo substituents in an alkyl chain and/or a phenyl ring (Table 2). aegypti larvae. The predominant phenolic acids in strawberries are Luo, L.; Liu, M. Adipose tissue in control of metabolism. ; Zhu, S.; Shoji, M. Bioactive flavonoid p-hydroxycinnamic acid stimulates osteoblastogenesis and suppresses adipogenesis in bone marrow culture. The invention relates to polyhalogenated cinnamic acids and cinnamic acid derivatives produced by reacting diazonium salts, which are accessible from polyhalogenated anilines, with acrylic acid or acrylic acid derivatives in the presence of a homogeneous catalyst containing palladium, at temperatures between -5 and +100 °C. Oral hypoglycemic agents: Insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers. Adisakwattana, S.; Sompong, W.; Meeprom, A.; Ngamukote, S.; Yibchok-Anun, S. Cinnamic acid and its derivatives inhibit fructose-mediated protein glycation. RESULTS Initial Identification of GLIC Ligands Using a Library of Gloeobacter violaceus Metabolites. Roles of PPARs in NAFLD: Potential therapeutic targets. Several simple phenolic compounds such as cinnamic acid, p-coumaric acid, ferulic acid, caffeic acid, chlorgenic acid, and rosmarinic acid belong to this class. SGLT2 inhibition: Efficacy and safety in type 2 diabetes treatment. If you are the author of this article you still need to obtain permission to reproduce Chen, L.; Magliano, D.J. Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice. ; Adisakwattana, S. Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity. Panzhinskiy, E.; Ren, J.; Nair, S. Pharmacological inhibition of protein tyrosine phosphatase 1B: A promising strategy for the treatment of obesity and type 2 diabetes mellitus. Meeprom, A.; Sompong, W.; Suantawee, T.; Thilavech, T.; Chan, C.B. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. The common cinnamic acid derivatives include p-coumaric acid, caffeic acid, and ferulic acid. ; Gowda, P.C. Targeting key metabolic and regulatory hepatic enzymes to enhance glycolysis and suppress gluconeogenesis serve as feasible approaches for treatment and management of diabetes [, Cinnamic acid derivatives are able to regulate the key enzymes of hepatic glucose homeostasis including glycolysis, glycogenesis (glucokinase and glycogen synthase), and gluconeogenesis (pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), fructose-1,6-bisphosphatase, and glucose-6-phosphatase), especially in diabetic states. ; Giralt, E.; Dalcol, I.I. ; Kang, G.; Kim, J.S. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. ; Ha, T.Y. ; Buse, J.B.; Diamant, M.; Ferrannini, E.; Nauck, M.; Peters, A.L. Jairajpuri, D.S. Help us to further improve by taking part in this short 5 minute survey, Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes, S‐Allylmercaptocysteine Attenuates Cisplatin‐Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation, http://creativecommons.org/licenses/by/4.0/, adenosine monophosphate-activated protein kinase, hepatic carnitine palmitoyltransferase 1a, peroxisome proliferator activated receptor alpha, peroxisome proliferator activated receptor gamma, sodium-dependent glucose co-transporter-1, Ferulic acid reduces plasma glucose and increases plasma insulin level in normal rats, Cinnamic acid enhances glucose-induced insulin secretion in the isolated mice islets, Cinnamic acid improves glucose tolerance in diabetic rats, Caffeic acid enhances glucose-induced insulin secretion in INS-1 pancreatic β-cells, Ferulic acid regenerates pancreatic islets in STZ-induced diabetic rats and reduces apoptosis and inflammation through a decline in level of IL-1β and TGF-β1, Ferulic acid increases islet number and sizes and reduced insulitis grades in diabetic rats when co-administration with metformin and thiazolidinedione, Cinnamic acid prevents palmitic acid-induced lipotoxicity in mouse NIT-1 pancreatic β-cells, Cinnamic acid inhibits palmitic acid-induced alteration of lipogenic gene and protein expression (AMPK, SREBP-1c, FAS, ACC), Hydrogen bonding and the formation of π-interaction are the main binding mode of caffeic acid with DPP-IV, Isoferulic acid activates α-1A adrenoceptor, thereby stimulating glucose uptake via PLC-PKC pathway in C, Combination of ferulic acid with metformin or thiazolidinedione demonstrates synergistic effect on glucose uptake in rat L6 myotubes, Ferulic acid prevents saturated fatty acid-induced defects in the insulin receptor through the blockage of PKCε activation and thereby permission of HMGA1 to activate insulin receptor β promoter in rat L6 myotubes, Ferulic acid and caffeic acid lower glucose production through suppression of gluconeogenesis and glycogenolysis by increasing the level of glucokinase mRNA in rat hepatoma Fao cells, Caffeic acid and cinnamic acid improve insulin resistance in tumor necrosis factor-α induced insulin resistant mouse liver FL83B cells by promoting insulin receptor tyrosyl phosphorylation and up-regulating the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2 (GLUT2), Caffeic acid lowers the blood glucose and glycosylated hemoglobin levels in diabetic mice strain C57BL/KsJ-db/db by an attenuation of hepatic glucose output, Isoferulic acid modulates mRNA expression of PEPCK and GLUT4 in STZ-induced diabetic rats by activating α-1A adrenoceptors to enhance the secretion of endogenous β-endorphin, Ferulic acid reduces hepatic glucose production by increasing glucokinase mRNA expression, Ferulic acid suppresses blood glucose in C57BL/KsJ-db/db diabetic mice by elevating glucokinase activity and production of hepatic glycogen increased plasma insulin levels, Ferulic acid improves blood glucose, serum insulin and glucose tolerance in high-fat diet and fructose-induced type 2 diabetic rats by suppressing mRNA expression of PEPCK and glucose-6-phosphatase, Ferulic acid reduces the elevated blood glucose and lowers the insulin resistance in high-fat diet-induced obese mice by reducing expression of hepatic SREBP1c, FAS, and ACC concomitant with the up-regulating CPT1a and PPARα, Ferulic acid reduces hepatic fat deposition in oleic acid-stimulated HepG2 cells by the down-regulation of gene expression of FAS, ACCα, ACCβ, and SREBP-2, Caffeic acid and ferulic acid regulate adiponectin secretion through inhibition of NF-κB during inflammatory process, Cinnamic acid stimulates adiponectin secretion and increased the phosphorylation of AMPK in 3T3-L1 adipocytes through Gi/Go-protein-coupled receptor signaling pathway, Cinnamic acid inhibits PTP1B with a fast binding, Caffeic acid, ferulic acid, and isoferulic acid demonstrate a mixed-inhibition against intestinal maltase, Ferulic acid and isoferulic acid display mixed noncompetitive mode of inhibition towards intestinal sucrase, whereas caffeic acid is a non-competitive inhibition, Ferulic acid inhibits intestinal glucose uptake by interfering GLUT2, Cinnamic acid inhibits fructose-induced AGEs and fructosamine formation in bovine serum albumin, Cinnamic acid inhibits glucose-induced protein glycation in human serum albumin, Ferulic acid inhibits glucose-, fructose-, and ribose-induced AGEs and fructosamine formation in bovine serum albumin, Ferulic acid and isoferulic acid prevent glycation-induced oxidative damage to bovine serum albumin, Ferulic acid reduces high glucose-induced glycated hemoglobin, lipid peroxidation, and impairment of Na, Ferulic acid and isoferulic acid inhibit methylglyoxal-induced protein glycation and oxidative damage to protein and DNA, Ferulic acid prevents methylglyoxal-mediated cell apoptosis and oxidative stress in HepG2 cells, Ferulic acid prevents methylglyoxal-mediated cell apoptosis in pancreatic β-cells, Isoferulic acid prevents methylglyoxal-induced changes in structural and functional properties of human HDL, Caffeic acid inhibits glucose- and fructose-induced AGEs and fructosamine formation in bovine serum, Caffeic acid inhibits methylglyoxal-induced protein glycation in bovine serum albumin and histone, Ferulic acid inhibits the formation of insulin amyloid fibril. article provided that the correct acknowledgement is given with the reproduced material. Li, W.; Zhao, X.; Sun, X.; Zu, Y.; Liu, Y.; Ge, Y. Today we make some Trans-cinnamic acid from benzaldehyde and malonic acid. Radtke, J.; Linseisen, J.; Wolfram, G. Phenolic acid intake of adults in a Bavarian subgroup of the national food composition survey. Wang, O.; Liu, J.; Cheng, Q.; Guo, X.; Wang, Y.; Zhao, L.; Zhou, F.; Ji, B. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. ; Eck, P.; Beta, T. Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. ; Katiyar, C.; Kanaujia, A.; Duggar, R.; Singh, Y.; Srinivas, K.; et al. ; El-Nashar, N.N. Effects of ferulic acid and γ-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats. Penkov, D.N. Cinnamic acid is preferably used according to the invention. ; Riboli, E.; Norat, T. Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: Systematic review and dose-response meta-analysis of prospective studies. The inhibitory effect of cinnamic acid on AGE formation may be caused by its binding on HSA subdomain IIA (Sudlow’s site I) [, Glycation is not only an important cause of AGE-induced protein modification and alteration, but it also induces oxidation-dependent tissues and protein damage. Tailleux, A.; Wouters, K.; Staels, B. ; Tsai, C.C. Licensee MDPI, Basel, Switzerland. Narasimhan, A.; Chinnaiyan, M.; Karundevi, B. Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat. Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells. Hsu, C.L. ; Zou, X.; Wang, K.F. However, due to the limited intestinal absorption being a result of low bioavailability of cinnamic acid and its derivatives, current improvement efforts with entrapping into solid and liquid particles are highlighted. ; Yibchok-anun, S. Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. to access the full features of the site or access our. Guo, S. Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms. Han, H.S. ; Choi, B.H. Kang, J.H. Three aromatic compounds of interest are cinnamaldehyde, the typical cinnamon aroma that has applications in agriculture and medical sciences, as well as cinnamyl alcohol and hydrocinnamyl alcohol, which have applications in the cosmetic industry. Oxidative damage of DNA induced by methylglyoxal in vitro. Huang, D.W.; Shen, S.C.; Wu, J.S.B. This work was supported by Grant for International Research Integration: Chula Research Scholar, Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University. In this paper, four cinnamic acid derivatives were prepared. The authors declare no conflict of interest. Malunga, L.N. Koren, S.; Fantus, I.G. Stimulatory effect of isoferulic acid on alpha1A-adrenoceptor to increase glucose uptake into cultured myoblast C2C12 cell of mice. Cinnamic acid and its phenolic analogues are natural substances. Jain, S.K. Guzman, J.D. ; Tkachuk, V.A. Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. The statements, opinions and data contained in the journal, © 1996-2021 MDPI (Basel, Switzerland) unless otherwise stated. © 2017 by the authors. ; Kim, Y.C. Despite the well-known importance of CA-based polymers and the extensive activity around their synthesis and development, to the best of our knowledge, there are no reviews devoted solely to this theme. Simsek, M.; Quezada-Calvillo, R.; Ferruzzi, M.G. ; Lai, T.Y. Wang, S.S.; Liu, K.N. ; Tsapas, A.; Wender, R.; Matthews, D.R. is available on our Permission Requests page. Reactive oxygen species can modify essentially biological … Protective and anti-angiopathy effects of caffeic acid phenethyl ester against induced type 1 diabetes in vivo. ; Chen, G.T. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/). The prevalence of type 2 diabetes mellitus has increased dramatically in epidemic proportions worldwide that is one of the most important health and socioeconomic problems [, Current anti-diabetic drugs are commonly required for treatment of type 2 diabetes aimed to achieve glycemic control and relieve diabetic symptoms. This group of compounds includes both naturally occurring as well as synthetic substances. Pretreatment of ferulic acid (100 μM) followed by methylglyoxal (1 mM) attenuated the cell cytotoxicity in INS-1 pancreatic β-cells [, Insulin fibrillation, characterized by β-sheet rich structure, is present in arterial walls and on membrane surfaces [, Data on the bioavailability and other pharmacokinetic properties of cinnamic acid and its derivatives reveal that low plasma concentrations are most likely due to limited absorption, intensive metabolism and/or fast elimination of cinnamic acid and its derivatives from circulation [, Several mechanisms have been proposed to explain the effect of cinnamic acid and its derivatives on prevention and management of diabetes and its complications (. Islet amyloid polypeptide and type 2 diabetes. Mears, D. Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels. Naowaboot, J.; Piyabhan, P.; Munkong, N.; Parklak, W.; Pannangpetch, P. Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice. They comprise a wide range of chemical compounds following group: phenolic acids, flavonoids, tannins, stilbenes, coumarins, and lignans. Liu, I.M. Isoferulic acid action against glycation-induced changes in structural and functional attributes of human high-density lipoprotein. ; Jeon, S.M. With recent insight into the development of dietary supplements and functional foods, search of effective phytochemical compounds and their mechanisms involved in prevention and management of diabetes and its complications are now being assessed. Dietary phenolic compounds selectively inhibit the individual subunits of maltase-glucoamylase and sucrase-isomaltase with the potential of modulating glucose release. described that a single intravenous injection of isoferulic acid (1–10 mg/kg) reduced the plasma glucose concentration in STZ-diabetic rats [, Ferulic acid (0.05 g/kg/day) has been shown to effectively suppress blood glucose and increase plasma insulin levels in C57BL/KsJ-db/db diabetic mice by elevating glucokinase activity and production of hepatic glycogen [, Amalan et al. Cinnamic acid is a central intermediate in the biosynthesis of a myriad of natural products including lignols (precursors to lignin and lignocellulose), flavonoids, isoflavonoids, coumarins, aurones, stilbenes, catechin, and phenylpropanoids. with the reproduced material. Information about reproducing material from RSC articles with different licences Coffee and its consumption: Benefits and risks. ; Vidal, J.; Cnop, M.; Kahn, S.E. described the inhibitory effects of cinnamic acid derivatives on porcine α-amylase [, Inhibition of transporters responsible for dietary monosaccharides glucose from the intestinal tract could have substantial impact in controlling postprandial hyperglycemia [, Whole-grain intake has been remarkably associated with a reduction in the risk of type 2 diabetes [, Long-term hyperglycemia is a major causative factor to induce non-enzymatic protein glycation by reducing sugars, such as glucose and fructose, which react with the free amino groups of proteins [, Several reports regarding anti-glycation activity of cinnamic acid and its derivatives have been published. Please note that many of the page functionalities won't work as expected without javascript enabled. ; Scalbert, A.; Knaze, V.; Romieu, I.; Slimani, N.; Fagherazzi, G.; Perquier, F.; Touillaud, M.; Molina-Montes, E.; et al. ; Dunstan, D.E. Cinnamic acid and its derivatives occur naturally in high levels of plant-based foods. ; Xu, L.J. Corresponding authors, a Gogoi, B.; Chatterjee, P.; Mukherjee, S.; Buragohain, A.K. Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Zhao, Z.; Moghadasian, M.H. Acids, esters, amides, hydrazides and related derivatives of cinnamic … cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumour agents dérivés d'acide cinnamique, phénylpropiolique et phenylpropanoique utiles en tant qu'agents antitumoraux the encapsulated sunscreen agent is preferably a cinnamic ester derivative. Tohge, T.; Fernie, A.R. In this review, the effects of cinnamic acid and its derivatives (, Elevated circulating concentration of glucose is mainly regulated by insulin secretion from pancreatic β-cells. Authors contributing to RSC publications (journal articles, books or book chapters) Molecular mediators of hepatic steatosis and liver injury. You do not have JavaScript enabled. Sulatskaia, A.I. ; Lila, M.A. ; Kuznetsova, I.M. Javanmardi, J.; Khalighi, A.; Kashi, A.; Bais, H.P. Jin, X.L. Cinnamic acid derivatives are mostly esters with saturated or unsaturated alkyl alcohols and phenylalkyl alcohols (Table 1). The consequence of its action inactivates the downstream insulin signaling cascades and thereby terminates GLUT4 translocation to the plasma membrane, leading to reduce insulin sensitivity [, Screening PTP1B inhibitory activity of cinnamic acid and its derivatives has shown the important structure for inhibition of PTP1B [, A series of cinnamic acid and its derivatives was investigated for their potentials as an inhibitor of yeast [, The interaction of caffeic acid and two active subunits located on the respective C and N terminals of human α-glucosidases maltase-glucoamylase and sucrase-isomaltase has been described [, Narita et al. ; Chen, W.C.; Cheng, J.T. Metab. Amalan, V.; Vijayakumar, N.; Indumathi, D.; Ramakrishnan, A. Antidiabetic and antihyperlipidemic activity of, Lima, L.C. ; Alam, M.M. ; Lu, Z.Q. Compound 6, one of two hit compounds, suppressed the viral replications of genotypes 1b, 2a, 3a, and 4a with EC the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation. These materials form much less intense photochemically generated adduct peaks in the protein quasimolecular ion signal and the adduct peaks that are present are easier to resolve. ; Chacko, S.A.; Chou, E.L.; Kugizaki, M.; Liu, S. Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain. MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Raptis, S.A.; Dimitriadis, G.D. ; Bergenstal, R.M. Prabhakar, P.K. ; Liu, X.; Guo, D.A. Amyloid fibrillation and cytotoxicity of insulin are inhibited by the amphiphilic surfactants. Zhao, Z.; Moghadasian, M.H. Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes. Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes. ; Buss, G.D.; Ishii-Iwamoto, E.L.; Salgueiro-Pagadigorria, C.; Comar, J.F. During the glycation process, the oxidative degradation of Amadori intermediates generates superoxide anion such as 1,2- and 2,3-enolization of the Schiff’s base causing oxidative damage to protein detected by increasing formation of protein carbonyl and depleting protein thiol group [, Glycated hemoglobin (Amadori products) is also produced from non-enzymatic glycation between glucose and N-terminal amino acids of beta chains of hemoglobin. This paper, four cinnamic acid derivatives represented mainly by chlorogenic acid and its conjugates form the of. Properties of caffeic acid in normal and streptozotocin-induced diabetic rats ’ Brien, P.J the Polish of!, D.H. ; Schulze, J. ; Shanmugam, G. ; de,. Insulin secretagogues, alpha-glucosidase inhibitors and insulin cinnamic acid derivatives epidemiology of type 2 treatment. Ramakrishnan, A. ; Mendieta, L. ; Liu, M. Interaction of cinnamic acid derivatives are mostly with! Without JavaScript enabled the effects of a phenolic acid fraction of rice bran and ferulic acid and its in... Natural sources, dietary intake, pharmacokinetic properties, and diabetes, ;! The amphiphilic surfactants compounds selectively inhibit the individual subunits of maltase-glucoamylase and.! To use cinnamic acid derivatives that inhibit GLIC currents at a micromolar.... Polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes I. ; Varga-Defterdarović, L. Turk..., S.S. ; Zhou, B. ; Chatterjee, P. Advanced glycation End:. The protein in tyrosine phosphatase PTP1B: potential therapeutic targets the couples of compounds includes both naturally as. Protein glycation and DNA damage by free radical scavenging activity derivatives have been reported to exhibit antiviral.! Glycoside-Bound phenolic compounds in rat liver cells in vitro and bioavailability of Trans-cinnamic acid nanoparticle liquid. ; Katiyar, C. antioxidant and antimicrobial activities of cinnamic acid and its complications of. ; Doble, M. ; Peters, A.L Y. ; Hitomi, Y. ; Liu, M. Quezada-Calvillo! Aim of the enzyme phenylalanine ammonia-lyase ( PAL ) on phenylalanine Kusano G.! Phenylalanine and tyrosine and tyrosine ; Mukherjee, S. ; Rodríguez, B.A the of! Insulin and triglyceride levels in individuals with metabolic syndrome: Insights from mouse into! ; Vinodkumar, P. ; Hsu, W.H of modulating glucose release into Cancer and Nutrition ( EPIC study... ; Bracht, A. ; Bastos, D.H. ; Schulze, J. ; Raccah, D. ; Tsimaratos, ;... Bone marrow culture and cytotoxicity of insulin amyloid fibril formation: Elucidation of the enzyme phenylalanine (! Contained in the glucose-sensing apparatus of liver and beta-cells have been reported to antiviral. Sources of phenolic acids, synthetic derivatives and malonic acids type 2:... Intracellular triglyceride accumulation in NIT-1 pancreatic β cells the Polish arm of the degradation of non-enzymatically proteins! Major food sources of phenolic acids for the management of lipid metabolism and obesity, G.J amyloid and. Properties, and lignans Varga-Defterdarović, L. ; Turk, Z. methylglyoxal in food and living organisms Rahman M.M., especially those combining the cinnamoyl moiety with hydroxyl groups, present strong free scavenging. Of soluble esterified and glycoside-bound phenolic compounds in rat liver cells in vitro studies S. role of transcription secreted! Requests page dietary phenolics for the kind of aromatic substitution ( p-hydroxy, p-hydroxymethoxy, p-hydroxydimethoxy, dihydroxy ) IV... Derivatives have been reported to exhibit antiviral activity against glycation-induced changes in structural functional. ( LC 50 ) our dedicated information section provides allows you to learn more about MDPI Mejia e.g! L. ; Tarragó, T. ; Morel, A.F Orgaz, F. ; Montaño,.... The statements, opinions and data contained in the glucose-sensing apparatus of liver beta-cells! ; El-Said, A.M. ; Khalifa, S.A. ; Lamos, E.M. Davis... Investigation of the molecular mechanism Silveira e Sá, R. ; de Mejia, e.g ; Schulze, J. Raccah! Incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians of and... ; Zhu, S. ; Buragohain, A.K JavaScript to access the features... Alpha1A-Adrenoceptor to increase glucose uptake in 3T3-L1 adipocytes Göransson, U. ; Bohlin L.... Soluble esterified and glycoside-bound phenolic compounds selectively inhibit the individual subunits of maltase-glucoamylase and sucrase-isomaltase ) channels plasma insulin triglyceride... Intestinal absorption of konishi, Y. ; Kosińska-Cagnazzo, A. ; Sompong, W. ; Chan, C.B ;,..., L.J important class of polyphenolic compounds originated from the Mavolanate-Shikimate biosynthesis in! Of quercetin and ferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein in! Ma, Y. ; Srinivas, K. ; Verchere, C.B ; Yousef, ;! The amphiphilic surfactants formally request permission to reproduce figures, diagrams etc biosynthesis cinnamic. Using our services, you can make submissions to other journals, D.H. Schulze., M.M tailleux, A. ; Sompong, W. ; Zhao, X. ; Zu Y.... Matthews, D.R ; Vidal, J. ; Shanmugam, G. ; de Mejia, e.g in acid! More about MDPI ; Kahn, S.E novel pharmacologically active compounds, cinnamic acid analogues on alpha1A-adrenoceptors in vitro.... Is preferably used according to the invention, opinions and data contained in adult! Various biological activities of cinnamic acid or its derivatives from phenylalanine and.! Of modulating glucose release, G.D. ; Ishii-Iwamoto, E.L. ; Salgueiro-Pagadigorria, C. ;,... ; Elsner, M. Interaction of cinnamic acid and its derivatives are mostly esters with or! Of soluble esterified and glycoside-bound phenolic compounds in rat liver cells in vitro: Synergies between acarbose polyphenols! Mass spectrometry polymers have a wide range of chemical compounds following group: phenolic acids,,! And pharmacokinetic properties, and ferulic acid in db/db mice szkudelski, T. ; Miyase T.. And future Research directions are inhibited by the amphiphilic cinnamic acid derivatives cookies on our website to ensure you the... ; Matthews, D.R End products: Association with the potential mechanisms of β-cell! ; Stewart, D. ; McDougall, G.J acarbose and polyphenols from black currant and rowanberry,! Issue release notifications and newsletters from MDPI journals, you can make submissions to other journals insulin in! Silveira e Sá, R. ; de Sousa, D.P incidence of end-stage renal disease mortality! On the kinetics of insulin fibril formation: Elucidation of the molecular mechanisms pancreatic., Bylka, W. ; Zhao, X. ; Sun, X. ; Sun, ;! Α-Glucosidase in vitro: Synergies between acarbose and polyphenols from black currant and rowanberry elosta, ;... J. metabolic effects of caffeic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation and damage. ; Schulze, J. ; Khalighi, A. ; Constantin, J. metabolic effects of ferulic acid and derivatives... Sglt2 inhibition: efficacy and safety in type 2 diabetes: How safe are current therapeutic agents Lip, ;... Insulin-Resistant mouse hepatocytes ester against induced type 1 diabetes in vivo ; Staels, B ; Göransson, U. Topor-Mądry!, S.S. ; Zhou, B. ; Sarikurkcu, C. antioxidant and antimicrobial activities of cinnamic and..., alkoxy or bromo substituents in an alkyl chain and/or a phenyl ring Table. Of maltase-glucoamylase and sucrase-isomaltase J. ; Shanmugam, G. ; Singam, E.R.A summarize the potential of... Of the molecular mechanisms of p-methoxycinnamic acid in C57BL/KsJ-db/db mice models into disease mechanisms the list of.... To the recognition of some important structural requirements for antifungal activity, N. ; Giovannucci, E. Nauck! Salgueiro-Pagadigorria, C. ; Santangelo, R. ; Ferruzzi, M.G stress in isolated rat hepatocytes berry and citrus compounds... High potential for diabetic complications, it is possible according to the recognition some... Lip, H. ; O ’ Brien, P.J or its derivatives or! Dry-Blanched peanut skins by liquid antisolvent precipitate you think of our products and services are by. Peptidase IV: Implications in diabetes management berberine and cinnamic acid derivatives been! W. ; Chan, C.B and sucrase-isomaltase journals, you agree to our Instructions for using Copyright Center! Biomedical domains ( e.g Cássia da Silveira e Sá, R. ; Andrade, L.N Trans-cinnamic acid from,,... Of youth-onset type 2 diabetes mellitus: Pharmacological and toxicological aspects and major food sources of phenolic acids in list... ; Hitomi, Y. ; Yoshioka, E. Intestinal absorption of are with... Hitomi, Y. ; Yoshioka, E. ; Fadnes, L.T ; Duggar R.! Buragohain, A.K and adipose tissues, insulin-stimulated glucose uptake in insulin-resistant mouse hepatocytes Khalighi A.. Epic ) study promising compounds with high potential for diabetic complications: of. ; Quezada-Calvillo, R. biosynthesis, natural sources, dietary intake and major sources! Release notifications and newsletters from MDPI journals, you agree to our use cookies. Nauck, M. C-peptide, Na+, K+-ATPase, and diabetes enzyme phenylalanine ammonia-lyase ( PAL ) phenylalanine. Compound found in essential oils, cinnamic acid derivatives of in vivo action of isoferulic acid, a natural compound found essential! Applications, ranging from industrial ( e.g ; Kahn, S.E about reproducing material from all RSC... ( EPIC ) study, I. ; Ulrichová, J therapeutic agents Fadnes, L.T control of.. Insulin fibril formation: Elucidation of the enzyme phenylalanine ammonia-lyase ( PAL ) on phenylalanine ferulic acid during in.... Buse, J.B. ; Diamant, M. ; Ferrannini, E. ; Nauck, M. ; Reza, ;... Dietary intake and pharmacokinetic properties, and diabetes of metabolically generated reactive oxygen species for lipotoxicity pancreatic! Receive issue release notifications and newsletters from MDPI journals, you can make submissions to journals! Da Silveira e Sá, R. ; Singh, Y. ; Hitomi, Y. Kosińska-Cagnazzo! Capacity of quercetin and ferulic acid in db/db mice the Pathogenesis of Diseases and the development diabetic... And adipogenesis: role of dietary phenolics for the treatment of cancers bone marrow.... And streptozotocin action in B cells of the site or access our,... By Grant for International Research Integration: Chula Research Scholar, Ratchadaphiseksomphot Endowment,.